Description

6-Chloro-4-(Trifluoromethyl)Pyridin-3-Amine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for creating compounds with tailored biological and physical properties. This specialty chemical is primarily demanded by the pharmaceutical and agrochemical industries for research and development, as well as process chemistry. Its role is pivotal in the synthesis of active ingredients and functional materials where specific electronic and steric characteristics are required.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances bioavailability and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands, organic electronic materials, and liquid crystals due to its electron-withdrawing substituents.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes, enzyme inhibitors, and other tools for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	6-Chloro-4-(Trifluoromethyl)Pyridin-3-Amine
CAS No.	1211590-44-1
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	3-Amino-6-chloro-4-(trifluoromethyl)pyridine; 6-Chloro-4-trifluoromethylpyridin-3-amine; 6-Chloro-4-(trifluoromethyl)-3-pyridinamine; 4-(Trifluoromethyl)-6-chloropyridin-3-amine; 3-Pyridinamine, 6-chloro-4-(trifluoromethyl)-; 6-Chloro-4-(trifluoromethyl)-3-aminopyridine
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-(Trifluoromethyl)Pyridin-3-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) with full traceability are provided for all shipments. We support development and commercial projects with material suitable for research use through to cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong acids, strong bases, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (HPLC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.