Description

6-(Trifluoromethyl)-1H-Pyrazolo[4,3-B]Pyridine is a high-value, multi-functional heterocyclic building block characterized by its fused pyrazolopyridine core and a strategically positioned trifluoromethyl group. This compound matters because the trifluoromethyl group is a critical pharmacophore known to enhance metabolic stability, lipophilicity, and binding affinity in active pharmaceutical ingredients. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel drug candidates, particularly in kinase inhibitor programs, and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key scaffold in the research and development of small molecule therapeutics, especially for oncology and inflammatory diseases.
• Kinase Inhibitor Synthesis: Serves as a privileged structure in creating potent and selective kinase inhibitors due to its ability to mimic adenine.
• Agrochemical Research: Used in developing new generation herbicides and pesticides where the CF3 group improves environmental stability and efficacy.
• Material Science: Potential building block for advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology: Useful as a probe or tag in biochemical assays and diagnostic development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D pipelines.

Basic Information

Product Name	6-(Trifluoromethyl)-1H-Pyrazolo[4,3-B]Pyridine
CAS No.	1211589-93-3
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	1H-Pyrazolo[4,3-b]pyridine, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine; 6-Trifluoromethyl-1H-pyrazolo[4,3-b]pyridine; 1211589-93-3; 6-(Trifluoromethyl)pyrazolo[4,3-b]pyridine; 6-Trifluoromethyl-pyrazolo[4,3-b]pyridine; Pyrazolo[4,3-b]pyridine, 6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)-1H-Pyrazolo[4,3-B]Pyridine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (High Purity Grades Available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.