Description

5-Bromo-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester is a high-value, multi-functional chemical intermediate designed for advanced synthesis. This compound matters for its unique trifluoroethoxy and bromo substituents, which are critical for modulating the biological activity, lipophilicity, and metabolic stability of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the trifluoroethoxy group for enhanced efficacy.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring complex heterocyclic chemistry.
• Material Science Research: Potential precursor for specialty chemicals and advanced materials with unique electronic properties.

Basic Information

Product Name	5-Bromo-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester
CAS No.	1211589-51-3
Molecular Formula	C9H7BrF3NO3
Molecular Weight	314.06 g/mol
Synonyms	Methyl 5-bromo-6-(2,2,2-trifluoroethoxy)nicotinate; 5-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester; 3-Pyridinecarboxylic acid, 5-bromo-6-(2,2,2-trifluoroethoxy)-, methyl ester; Methyl 5-bromo-6-((trifluoroethoxy))nicotinate; 5-Bromo-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in pharmaceutical R&D and other critical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.