Description

3-Bromo-2-Chloro-4-(Trifluoromethyl)Pyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogenated pyridine core contributes to bioactivity.
• Material Science Precursor: Employed in the synthesis of functional ligands for catalysis and as a building block for specialty polymers and electronic materials.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: The bromine and chlorine substituents make it an excellent substrate for selective Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions.

Basic Information

Product Name	3-Bromo-2-Chloro-4-(Trifluoromethyl)Pyridine
CAS No.	1211588-39-4
Molecular Formula	C6H2BrClF3N
Molecular Weight	260.44 g/mol
Synonyms	2-Chloro-3-bromo-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-3-bromo-2-chloropyridine; 3-Bromo-2-chloro-4-trifluoromethylpyridine; Pyridine, 3-bromo-2-chloro-4-(trifluoromethyl)-; 1211588-39-4; 2-Chloro-3-bromo-4-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-2-Chloro-4-(Trifluoromethyl)Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support custom purity requirements for specific R&D or scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.