Description

2-(Difluoromethoxy)Pyridin-4-Amine is a specialized pyridine derivative featuring a difluoromethoxy substituent, a structural motif of significant interest in modern synthetic chemistry. This compound serves as a critical high-purity building block for the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily utilized by research and development (R&D) teams and process chemists in the pharmaceutical and agrochemical industries seeking to incorporate fluorine-containing heterocycles into their molecular designs.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel nitrogen-containing ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials requiring fluorinated aromatic amines.
• Chemical Biology Probes: Utilized as a building block for synthesizing fluorescent tags or molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	2-(Difluoromethoxy)Pyridin-4-Amine
CAS No.	1211587-46-0
Molecular Formula	C6H6F2N2O
Molecular Weight	160.12 g/mol
Synonyms	4-Amino-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-4-pyridinamine; 4-Pyridinamine, 2-(difluoromethoxy)-; 2-Difluoromethoxypyridin-4-ylamine; 2-(Difluoromethoxy)-4-aminopyridine; 4-Amino-2-(difluoromethoxy)pyridine; 1211587-46-0
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Pyridin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high-purity standards required for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.