Description

5-Ethynyl-3-Fluoro-2-Methoxypyridine is a high-purity, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is valued for its unique molecular architecture, which combines an ethynyl group for click chemistry or cross-coupling reactions with fluorine and methoxy substituents that modulate electronic properties and bioavailability. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and CNS-active molecule libraries.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and plant growth regulators, leveraging the fluorine atom for enhanced metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands or monomers in the development of advanced polymers and organic electronic materials.
• Chemical Biology & Proteomics: The ethynyl group enables bioorthogonal labeling (e.g., via CuAAC click chemistry) for tagging and studying biomolecules.
• Cross-Coupling Reactions: Acts as a versatile coupling partner in Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed reactions to construct complex biaryl systems.

Basic Information

Product Name	5-Ethynyl-3-Fluoro-2-Methoxypyridine
CAS No.	1211587-10-8
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	3-Fluoro-2-methoxy-5-ethynylpyridine; 2-Methoxy-3-fluoro-5-ethynylpyridine; 5-Ethynyl-3-fluoro-2-methoxypyridine; 1211587-10-8; 3-Fluoro-5-ethynyl-2-methoxypyridine; 5-Ethynyl-3-fluoro-2-pyridinol methyl ether
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-3-Fluoro-2-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development projects with custom purity grades and analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.