Description

6-Amino-2-Aza-Spiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a constrained spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and target selectivity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small molecule drugs, particularly those targeting central nervous system (CNS) disorders.
• Proteolysis Targeting Chimera (PROTAC) Development: Used to construct the linker or warhead components of bifunctional molecules designed for targeted protein degradation.
• Peptidomimetic Chemistry: The spirocyclic, rigid structure serves as a non-natural amino acid surrogate to confer conformational restraint in peptide-based drug design.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for investigating biological pathways and target validation.
• Agrochemical Research: Potential intermediate for creating new active ingredients with unique biological activity profiles.
• Academic & Contract Research: Serves as a specialized reagent for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	6-Amino-2-Aza-Spiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1211586-09-2
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-amino-, 1,1-dimethylethyl ester; 6-Amino-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; 2-Boc-2,6-diazaspiro[3.3]heptane; 2-(tert-Butoxycarbonyl)-2,6-diazaspiro[3.3]heptane; 6-Amino-2-azaspiro[3.3]heptane-2-carboxylate tert-butyl ester; Boc-2,6-diazaspiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our 6-Amino-2-Aza-Spiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.