Description

4-Chloro-2-Fluoropyridine-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated pyridine core structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily targeted at research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen and carboxylic acid functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogenated pyridine moiety contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloro-2-Fluoropyridine-3-Carboxylic Acid
CAS No.	1211584-03-0
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.55 g/mol
Synonyms	3-Carboxy-4-chloro-2-fluoropyridine; 2-Fluoro-4-chloropyridine-3-carboxylic acid; 4-Chloro-2-fluoro-3-pyridinecarboxylic acid; 4-Chloro-2-fluoronicotinic acid; 2-Fluoro-4-chloronicotinic acid; 3-Pyridinecarboxylic acid, 4-chloro-2-fluoro-; 1211584-03-0 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Fluoropyridine-3-Carboxylic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (IR, NMR), and impurity profile is supplied with each shipment to guarantee traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.