Description

5-(2,2,2-Trifluoro-Ethoxy)-Nicotinonitrile is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoroethoxy substituent, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, particularly in medicinal chemistry for creating novel drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel small-molecule drugs, especially kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine moiety contributes to biological activity and environmental persistence.
• Material Science Research: Employed in the synthesis of specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Serves as a precursor for labeled compounds and probes used in biochemical assays and diagnostic research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and process development projects.
• Academic Research: Utilized in university and institutional laboratories for methodological studies in fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	5-(2,2,2-Trifluoro-Ethoxy)-Nicotinonitrile
CAS No.	1211581-84-8
Molecular Formula	C9H5F3N2O
Molecular Weight	214.14 g/mol
Synonyms	3-Cyano-5-(2,2,2-trifluoroethoxy)pyridine; Nicotinonitrile, 5-(2,2,2-trifluoroethoxy)-; 5-(2,2,2-Trifluoroethoxy)-3-pyridinecarbonitrile; 5-(Trifluoroethoxy)nicotinonitrile; 3-Pyridinecarbonitrile, 5-(2,2,2-trifluoroethoxy)-
EINECS	Contact for details

Quality Control

Our 5-(2,2,2-Trifluoro-Ethoxy)-Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.