Description

2-Ethynyl-Isonicotinonitrile is a high-purity, specialized organic building block featuring both a nitrile and an ethynyl functional group on a pyridine core. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex heterocyclic compounds and active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for developing new drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides requiring specific heterocyclic scaffolds.
• Material Science Research: Serves as a precursor for organic electronic materials and metal-organic frameworks (MOFs) due to its ethynyl group.
• Ligand and Catalyst Development: Employed in creating specialized ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems via click chemistry.

Basic Information

Product Name	2-Ethynyl-Isonicotinonitrile
CAS No.	1211580-87-8
Molecular Formula	C8H4N2
Molecular Weight	128.13 g/mol
Synonyms	2-Ethynylpyridine-4-carbonitrile; 4-Cyano-2-ethynylpyridine; Isonicotinonitrile, 2-ethynyl-; 2-Ethynylisonicotinonitrile; 2-Ethynyl-4-pyridinecarbonitrile; 4-Pyridinecarbonitrile, 2-ethynyl-; 2-Ethynyl-4-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-Isonicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.