Description

4-Bromo-2-(Difluoromethyl)Pyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethyl substituents, offers versatile reactivity for introducing fluorinated motifs and enabling cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Employed in the synthesis of functionalized ligands for catalysis, liquid crystals, and advanced polymeric materials.
• Cross-Coupling Reactions: Serves as a versatile electrophile in Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions to form biaryl and heterobiaryl structures.
• Fluorine Chemistry Building Block: The difluoromethyl group acts as a valuable bioisostere, making this compound crucial for medicinal chemistry programs exploring fluorinated analogs.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on heterocyclic chemistry, fluorination strategies, and new synthetic methodologies.

Basic Information

Item	Details
Product Name	4-Bromo-2-(Difluoromethyl)Pyridine
CAS No.	1211580-54-9
Molecular Formula	C7H4BrF2N
Molecular Weight	208.01 g/mol
Synonyms	2-(Difluoromethyl)-4-bromopyridine; 4-Bromo-2-difluoromethylpyridine; Pyridine, 4-bromo-2-(difluoromethyl)-; 4-Bromo-2-(difluoromethyl)pyridine; 1211580-54-9
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Difluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.