Description

2-Chloro-4-Ethynyl-5-Fluoropyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique molecular architecture, featuring a reactive ethynyl group alongside halogen substituents, makes it a critical intermediate for constructing complex molecular scaffolds. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Ligand Synthesis: Employed in the creation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems, enabled by the reactive alkyne group for click chemistry.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-4-Ethynyl-5-Fluoropyridine
CAS No.	1211539-66-0
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	5-Fluoro-2-chloro-4-ethynylpyridine; 4-Ethynyl-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoro-4-ethynylpyridine; 5-Fluoro-4-ethynyl-2-chloropyridine; 2-Chloro-4-ethynyl-5-fluoro-pyridine; Pyridine, 2-chloro-4-ethynyl-5-fluoro-; CAS 1211539-66-0
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Ethynyl-5-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.