Description

Methyl 3-Bromo-6-(Trifluoromethyl)Picolinate is a high-value, multi-functional chemical intermediate characterized by its bromine and trifluoromethyl substituents. This compound is essential for facilitating complex molecular transformations in advanced synthetic chemistry, offering a strategic balance of reactivity and stability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings for carbon-carbon bond formation.
• Functional Group Transformation: Utilized in medicinal chemistry for the introduction of the picolinate ester moiety and subsequent derivatization.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	Methyl 3-Bromo-6-(Trifluoromethyl)Picolinate
CAS No.	1211538-62-3
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	Methyl 3-bromo-6-(trifluoromethyl)pyridine-2-carboxylate; 3-Bromo-6-(trifluoromethyl)picolinic acid methyl ester; 2-Pyridinecarboxylic acid, 3-bromo-6-(trifluoromethyl)-, methyl ester; Methyl 3-bromo-6-trifluoromethylpicolinate; 3-Bromo-6-trifluoromethyl-picolinic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Bromo-6-(Trifluoromethyl)Picolinate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against established internal specifications using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.