Description

4-(Piperidin-4-Yloxy)Pyridine-2-Carboxamide is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1211536-73-0. This compound is a critical building block in modern medicinal chemistry, valued for its unique molecular scaffold that enables the synthesis of targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a crucial component in the synthesis of compounds targeting specific protease enzymes.
• Kinase Inhibitor Development: Employed in the construction of potential kinase inhibitor candidates for oncology applications.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	4-(Piperidin-4-Yloxy)Pyridine-2-Carboxamide
CAS No.	1211536-73-0
Molecular Formula	C11H15N3O2
Molecular Weight	221.26 g/mol
Synonyms	4-[(4-Piperidinyl)oxy]-2-pyridinecarboxamide; 4-(Piperidin-4-yloxy)picolinamide; 2-Pyridinecarboxamide, 4-[(4-piperidinyl)oxy]-; 4-(4-Piperidyloxy)pyridine-2-carboxamide; Picolinamide, 4-(4-piperidinyloxy)-; 1211536-73-0; 4-Piperidin-4-yloxy-pyridine-2-carboxylic acid amide
EINECS	Contact for details

Quality Control

Our 4-(Piperidin-4-Yloxy)Pyridine-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with research-grade or cGMP standards based on customer requirements to support various stages of the drug development pipeline.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.