Description

6-Bromo-2-(Difluoromethyl)Pyridine-3-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique molecular architecture, which combines a bromo-substituent for cross-coupling reactions with a difluoromethyl group and a carboxylic acid moiety for further derivatization. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic pyridine core and functional handles.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	6-Bromo-2-(Difluoromethyl)Pyridine-3-Carboxylic Acid
CAS No.	1211536-36-5
Molecular Formula	C7H4BrF2NO2
Molecular Weight	251.99 g/mol
Synonyms	3-Pyridinecarboxylic acid, 6-bromo-2-(difluoromethyl)-; 6-Bromo-2-(difluoromethyl)nicotinic acid; 2-(Difluoromethyl)-6-bromopyridine-3-carboxylic acid; 6-Bromo-2-difluoromethylnicotinic acid; 1211536-36-5; 6-Bromo-2-(difluoromethyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(Difluoromethyl)Pyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.