Description

5-Chloro-2-Methyl-3-Nitropyridine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the construction of complex molecular architectures in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and photoactive compounds.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to introduce complex substituents.
• Nucleophilic Aromatic Substitution: The chloro and nitro groups provide distinct sites for selective nucleophilic displacement, enabling sequential functionalization.

Basic Information

Product Name	5-Chloro-2-Methyl-3-Nitropyridine
CAS No.	1211533-93-5
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	3-Nitro-5-chloro-2-picoline; 2-Methyl-5-chloro-3-nitropyridine; 5-Chloro-2-methyl-3-nitro-pyridine; 2-Picoline, 5-chloro-3-nitro-; 3-Nitro-5-chloro-2-methylpyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Methyl-3-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.