Description

5-Ethynylnicotinic Acid is a high-purity, functionalized pyridine derivative featuring a terminal alkyne group. This unique bifunctional structure makes it a versatile and valuable building block for advanced organic synthesis, particularly in the development of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as click chemistry, cross-coupling reactions, and ligand synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs) and drug candidates via Sonogashira coupling and other metal-catalyzed reactions.
• Click Chemistry Reagent: The terminal alkyne group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition, CuAAC) for bioconjugation and polymer functionalization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands for transition metal catalysis and organometallic complexes.
• Material Science Building Block: Incorporated into organic frameworks, polymers, and advanced materials to impart specific electronic or structural properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Item	Details
Product Name	5-Ethynylnicotinic Acid
CAS No.	1211533-87-7
Molecular Formula	C8H5NO2
Molecular Weight	147.13 g/mol
Synonyms	3-Carboxy-5-ethynylpyridine; 5-Ethynyl-3-pyridinecarboxylic Acid; Nicotinic acid, 5-ethynyl-; 5-Ethynylpyridine-3-carboxylic Acid; 3-Pyridinecarboxylic acid, 5-ethynyl-
EINECS	Contact for details

Quality Control

Every batch of 5-Ethynylnicotinic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide a Certificate of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and development applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.