Description

5-Bromo-2-Chloro-3-Difluoromethoxy-Pyridine is a high-purity halogenated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique substitution pattern, which provides versatile reactivity for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy and halogen groups contribute to biological activity and metabolic stability.
• Material Science Precursor: Employed in the development of specialty chemicals, liquid crystals, and functional materials that require specific halogenated heterocyclic cores.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and process development projects requiring high-fidelity halogenated pyridines.
• Academic & Industrial R&D: Serves as a versatile scaffold in medicinal chemistry and chemical biology for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	5-Bromo-2-Chloro-3-Difluoromethoxy-Pyridine
CAS No.	1211533-38-8
Molecular Formula	C7H3BrClF2NO
Molecular Weight	274.46 g/mol
Synonyms	3-(Difluoromethoxy)-5-bromo-2-chloropyridine; 2-Chloro-5-bromo-3-(difluoromethoxy)pyridine; 5-Bromo-2-chloro-3-(difluoromethoxy)pyridine; Pyridine, 5-bromo-2-chloro-3-(difluoromethoxy)-; 1211533-38-8
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Chloro-3-Difluoromethoxy-Pyridine is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.