Description

2-Chloro-5-Fluoro-Nicotinic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, offering precise structural control for complex molecule construction. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides with improved efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis.
• Material Science Research: Employed in the synthesis of functionalized heterocyclic compounds for advanced materials.
• Custom Synthesis and Contract Manufacturing: A versatile starting material for bespoke chemical synthesis services.
• Academic and Industrial R&D: Fundamental reagent for methodological studies and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	2-Chloro-5-Fluoro-Nicotinic Acid
CAS No.	1211533-26-4
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.55 g/mol
Synonyms	2-Chloro-5-fluoropyridine-3-carboxylic acid; 3-Carboxy-2-chloro-5-fluoropyridine; 5-Fluoro-2-chloronicotinic acid; 2-Chloro-5-fluoro-3-pyridinecarboxylic acid; Nicotinic acid, 2-chloro-5-fluoro-; 1211533-26-4; 2-Chloro-5-fluoronicotinic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.