Description

5-Bromo-2-Trifluoromethyl-Pyridin-3-Ylamine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a bromine substituent and a trifluoromethyl group on the pyridine ring, enabling precise molecular modifications and introducing desirable physicochemical properties. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for functionalized ligands, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig) to form complex biaryl structures.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution on molecular properties like lipophilicity, bioavailability, and binding affinity.
• Ligand and Catalyst Development: Used to synthesize novel nitrogen-containing ligands for metal complexes used in catalysis.

Basic Information

Item	Detail
Product Name	5-Bromo-2-Trifluoromethyl-Pyridin-3-Ylamine
CAS No.	1211533-18-4
Molecular Formula	C7H4BrF3N2
Molecular Weight	241.02 g/mol
Synonyms	3-Amino-5-bromo-2-(trifluoromethyl)pyridine; 5-Bromo-2-(trifluoromethyl)pyridin-3-amine; 5-Bromo-2-trifluoromethyl-3-pyridinamine; 2-Trifluoromethyl-5-bromo-3-aminopyridine; 3-Pyridinamine, 5-bromo-2-(trifluoromethyl)-; 5-Bromo-2-(trifluoromethyl)-3-pyridylamine; 5-Bromo-2-(trifluoromethyl)-3-aminopyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Trifluoromethyl-Pyridin-3-Ylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and other relevant methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.