Description

6-Methoxy-5-(trifluoromethyl)nicotinic acid is a high-value, multi-functional chemical intermediate characterized by its unique trifluoromethyl and methoxy-substituted pyridine core. This compound is essential for the synthesis of advanced molecules, offering significant advantages in modulating the physicochemical and metabolic properties of target compounds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients. Its structural features make it a critical building block for developing products with enhanced potency, selectivity, and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	6-Methoxy-5-(Trifluoromethyl)Nicotinic Acid
CAS No.	1211532-15-8
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	5-(Trifluoromethyl)-6-methoxynicotinic acid; 6-Methoxy-5-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-methoxy-5-(trifluoromethyl)-; 1211532-15-8; 6-Methoxy-5-trifluoromethylnicotinic acid; 5-Trifluoromethyl-6-methoxy-nicotinic acid; Nicotinic acid, 6-methoxy-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 6-Methoxy-5-(trifluoromethyl)nicotinic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.