Description

2-(Difluoromethyl)Pyridine-4-Carbonitrile, 4-Cyano-2-(Difluoromethyl)Pyridine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both a difluoromethyl group and a nitrile moiety on a pyridine core, makes it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where its fluorine content can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Building Block: A valuable reagent for introducing fluorine atoms into complex molecular architectures in medicinal and synthetic chemistry programs.

Basic Information

Product Name	2-(Difluoromethyl)Pyridine-4-Carbonitrile, 4-Cyano-2-(Difluoromethyl)Pyridine
CAS No.	1211528-71-0
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	4-Cyano-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)isonicotinonitrile; 2-(Difluoromethyl)-4-pyridinecarbonitrile; 4-Pyridinecarbonitrile, 2-(difluoromethyl)-; Isonicotinonitrile, 2-(difluoromethyl)-; 1211528-71-0; 2-Difluoromethylpyridine-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)Pyridine-4-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP and ISO 9001 compliant production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.