Description

3-Chloro-5-Chloromethyl-2-Fluoro-Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring reactive chloro and chloromethyl groups on a fluorinated pyridine ring, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized nitrogen-containing ligands used in transition metal catalysis.
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Chloro-5-Chloromethyl-2-Fluoro-Pyridine
CAS No.	1211525-34-6
Molecular Formula	C6H4Cl2FN
Molecular Weight	180.01 g/mol
Synonyms	2-Fluoro-3-chloro-5-(chloromethyl)pyridine; 5-(Chloromethyl)-3-chloro-2-fluoropyridine; 3-Chloro-2-fluoro-5-(chloromethyl)pyridine; 2-Fluoro-3-chloro-5-chloromethylpyridine; Pyridine, 3-chloro-5-(chloromethyl)-2-fluoro-; (3-Chloro-2-fluoropyridin-5-yl)methyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Chloromethyl-2-Fluoro-Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.