Description

2-Bromo-5-Chloro-4-Methoxypyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique substitution pattern, which provides multiple reactive sites for selective functionalization, enabling the construction of complex molecular architectures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a precursor for functionalized ligands and monomers used in the creation of specialty polymers and advanced materials.
• Chemical Synthesis: An essential building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions such as Suzuki, Stille, or Buchwald-Hartwig amination due to the reactive bromo substituent.

Basic Information

Product Name	2-Bromo-5-Chloro-4-Methoxypyridine
CAS No.	1211520-39-6
Molecular Formula	C6H5BrClNO
Molecular Weight	222.47 g/mol
Synonyms	2-Bromo-5-chloro-4-methoxypyridine; 4-Methoxy-2-bromo-5-chloropyridine; 5-Chloro-2-bromo-4-methoxypyridine; 2-Bromo-5-chloro-4-pyridinol methyl ether; Pyridine, 2-bromo-5-chloro-4-methoxy-; 1211520-39-6
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Chloro-4-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.