Description

6-(1,1-Difluoroethyl)Pyridine-3-Carboxylic Acid is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced chemical synthesis. Its core value lies in the strategic incorporation of a difluoroethyl group, which can significantly alter the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	6-(1,1-Difluoroethyl)Pyridine-3-Carboxylic Acid
CAS No.	1211515-90-0
Molecular Formula	C8H7F2NO2
Molecular Weight	187.15 g/mol
Synonyms	3-Pyridinecarboxylic acid, 6-(1,1-difluoroethyl)-; 6-(1,1-Difluoroethyl)nicotinic acid; 2-(1,1-Difluoroethyl)pyridine-5-carboxylic acid; 5-Carboxy-2-(1,1-difluoroethyl)pyridine; Nicotinic acid, 6-(1,1-difluoroethyl)-; 1211515-90-0; 6-(Difluoroethyl)nicotinic acid
EINECS	Contact for details

Quality Control

Our production of 6-(1,1-Difluoroethyl)Pyridine-3-Carboxylic Acid adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.