Description

1-tert-Butylsulfinyl-5-Oxa-1-Azaspiro[2,3]Hexane is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and oxazolidine scaffold. This compound is critical for enabling complex synthetic routes in modern medicinal chemistry, particularly for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce structural complexity and specific stereochemistry into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Chiral Auxiliary/Synthon: The tert-butylsulfinyl group acts as a versatile chiral directing agent for asymmetric synthesis, enabling the creation of enantiomerically pure compounds.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the spirocyclic structure can confer unique biological activity and stability.
• Ligand Precursor: Can be modified to create novel ligands for catalysis in asymmetric hydrogenation or cross-coupling reactions.
• Academic & Institutional R&D: A valuable reagent for methodological studies in organic synthesis and heterocyclic chemistry at universities and research institutes.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals beyond pharmaceuticals.

Basic Information

Product Name	1-tert-Butylsulfinyl-5-Oxa-1-Azaspiro[2,3]Hexane
CAS No.	1211284-25-1
Molecular Formula	C9H17NO2S
Molecular Weight	203.30 g/mol
Synonyms	1-[(Tert-butyl)sulfinyl]-5-oxa-1-azaspiro[2.3]hexane; 5-Oxa-1-azaspiro[2.3]hexane, 1-[(1,1-dimethylethyl)sulfinyl]-; 1-(tert-Butylsulfinyl)-5-oxa-1-azaspiro[2.3]hexane; tert-Butylsulfinyl Oxazaspirohexane; N-tert-Butylsulfinyl-5-oxa-1-azaspiro[2.3]hexane; (S)- or (R)-1-tert-Butylsulfinyl-5-oxa-1-azaspiro[2.3]hexane (enantiomers); Spiro[cyclopropane-1,2'-[1,3]oxazolidine], 1'-[(1,1-dimethylethyl)sulfinyl]- (systematic name)
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butylsulfinyl-5-Oxa-1-Azaspiro[2,3]Hexane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity (if applicable), and impurity profile is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade) or as specified
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.