Description

Methyl 6-(3-(1H-Tetrazol-5-Yl)Phenoxy)Nicotinate is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining nicotinate and tetrazole pharmacophores. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting cardiovascular, metabolic, and inflammatory disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, especially those targeting angiotensin II receptors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies due to its tetrazole and pyridine functionalities.
• API Development: A key building block in the production of advanced active pharmaceutical ingredients (APIs) for hypertension and heart failure medications.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard in analytical method development for pharmacokinetic studies.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	Methyl 6-(3-(1H-Tetrazol-5-Yl)Phenoxy)Nicotinate
CAS No.	1208942-12-4
Molecular Formula	C14H11N5O3
Molecular Weight	297.27 g/mol
Synonyms	Methyl 6-[3-(1H-tetrazol-5-yl)phenoxy]nicotinate; 6-(3-(1H-Tetrazol-5-yl)phenoxy)nicotinic acid methyl ester; Methyl 6-(3-(2H-tetrazol-5-yl)phenoxy)pyridine-3-carboxylate; Nicotinic acid, 6-[3-(1H-tetrazol-5-yl)phenoxy]-, methyl ester; 1208942-12-4; Methyl 6-(3-(tetrazol-5-yl)phenoxy)nicotinate
EINECS	Contact for details

Quality Control

Our Methyl 6-(3-(1H-Tetrazol-5-Yl)Phenoxy)Nicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the high standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.