Description

8-Bromo-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one is a high-value heterocyclic organic compound featuring a fused triazolopyridine scaffold with a bromine substituent. This structure makes it a versatile and critical pharmaceutical intermediate for medicinal chemistry research and drug development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to synthesize novel active compounds.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive bromine site for further functionalization.
• Agrochemical Development: Acts as a precursor in the research and synthesis of novel herbicides, fungicides, or insecticides.
• Chemical Biology Probes: Employed in the design and creation of molecular probes for studying biological pathways and target engagement.
• Material Science Research: Investigated as a monomer or precursor for advanced organic electronic materials or polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects.

Basic Information

Product Name	8-Bromo-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
CAS No.	1207970-25-9
Molecular Formula	C6H4BrN3O
Molecular Weight	214.02 g/mol
Synonyms	8-Bromo-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one; 8-Bromo-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one; 8-Bromo-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine; 1207970-25-9; 8-Bromo-2H-[1,2,4]triazolo[4,3-a]pyridin-3-ol (tautomer); 8-Bromotriazolopyridinone
EINECS	Contact for details

Quality Control

Our 8-Bromo-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.