Description

2-(p-Tolylsulfonyl)-6-Oxa-2-Azaspiro[2.5]Octane is a specialized spirocyclic sulfonamide building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring a strained oxazaspiro ring system, makes it a valuable precursor for constructing complex nitrogen- and oxygen-containing heterocycles. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel spirocyclic drug candidates, particularly in central nervous system (CNS) and anti-infective research.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study biological pathways and protein function.
• Advanced Material Synthesis: A potential monomer or cross-linker for creating polymers with specific thermal or mechanical properties.
• Methodology Development: Employed in academic and industrial research to develop new synthetic methodologies involving strained ring systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, multi-step transformations.

Basic Information

Product Name	2-(p-Tolylsulfonyl)-6-Oxa-2-Azaspiro[2.5]Octane
CAS No.	1207754-85-5
Molecular Formula	C13H17NO3S
Molecular Weight	267.35 g/mol
Synonyms	2-(4-Methylphenyl)sulfonyl-6-oxa-2-azaspiro[2.5]octane; 6-Oxa-2-azaspiro[2.5]octane, 2-[(4-methylphenyl)sulfonyl]-; 2-(Tosyl)-6-oxa-2-azaspiro[2.5]octane; 2-(p-Toluenesulfonyl)-6-oxa-2-azaspiro[2.5]octane; Spiro[oxirane-2,1'-azetidine], 2'-[(4-methylphenyl)sulfonyl]tetrahydro-2H-furan derivative; TS-OA Spiroether; p-Tolylsulfonyl Oxazaspirooctane
EINECS	Contact for details

Quality Control

Our 2-(p-Tolylsulfonyl)-6-Oxa-2-Azaspiro[2.5]Octane is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.