Description

5-Ethynyl-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a versatile ethynyl-substituted heterocyclic core. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of targeted small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable ethynyl group.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study biological pathways and protein function.
• Bioconjugation: The ethynyl moiety enables efficient conjugation via click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) for labeling and linker applications.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP-like conditions.

Basic Information

Product Name	5-Ethynyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1207351-16-3
Molecular Formula	C9H6N2
Molecular Weight	142.16 g/mol
Synonyms	5-Ethynyl-7-azaindole; 5-Ethynyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-ethynyl-; 5-Ethynyl-1H-7-azaindole; 5-Ethynyl-7-aza-indole; 5-Ethynyl-7-azaindole (7-Azaindole, 5-ethynyl-); 5-Ethynyl-1H-pyrrolo[2,3-b]pyridine (1207351-16-3)
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.