Description

Rac-Trans 3’-Hydroxymethylnicotine Hemisuccinate n-Hydroxysuccinimide Ester is a high-purity, advanced pharmaceutical intermediate and biochemical reagent. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis and study of nicotine analogs and related bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on neuroscience and addiction research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nicotine derivatives and receptor ligands for therapeutic development.
• Biochemical Research: Used as a precise tool compound in studies targeting nicotinic acetylcholine receptors (nAChRs) to understand signaling pathways.
• Medicinal Chemistry: Serves as a crucial precursor for structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Reference Standard: Employed as an analytical standard in quality control and method development for pharmacokinetic and metabolic studies.
• Neuroscience Research: Facilitates the development of probes and tracers for neuroimaging and receptor binding assays.

Basic Information

Product Name	Rac-Trans 3’-Hydroxymethylnicotine Hemisuccinate n-Hydroxysuccinimide Ester
CAS No.	1207282-60-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3'-Hydroxymethylnicotine hemisuccinate NHS ester; (Rac)-Trans-3'-Hydroxymethylnicotine hemisuccinate N-hydroxysuccinimide ester; 3'-(Hydroxymethyl)nicotine hemisuccinate active ester; Nicotine-3'-ylmethyl hemisuccinate N-succinimidyl ester; NHS ester of 3'-hydroxymethylnicotine hemisuccinate
EINECS	Contact for details

Quality Control

Our Rac-Trans 3’-Hydroxymethylnicotine Hemisuccinate n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.