Description

1-Boc-4-Bromomethyl-4-Fluoropiperidine is a high-value, multi-functional piperidine derivative that serves as a critical building block in modern synthetic chemistry. This compound is specifically engineered to facilitate the efficient construction of complex molecular architectures, offering precise control over stereochemistry and functional group introduction. It is an essential intermediate for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated piperidine-based active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs, kinase inhibitors, and other therapeutic small molecules.
• Agrochemical Research: Used in the development of novel fluorinated pesticides and herbicides, where the fluorine atom and the reactive bromomethyl group can enhance biological activity and environmental stability.
• Chemical Biology & Proteomics: Employed as a versatile linker or scaffold for creating chemical probes, affinity tags, and PROTAC (Proteolysis Targeting Chimeras) molecules for target identification and validation.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Medicinal Chemistry SAR Studies: Facilitates Structure-Activity Relationship (SAR) exploration by allowing modular introduction of the fluoropiperidine moiety into diverse lead compound libraries.
• Peptidomimetics Development: Serves as a constrained, fluorinated amino acid analog for designing novel peptide mimics with improved metabolic stability and binding affinity.

Basic Information

Product Name	1-Boc-4-Bromomethyl-4-Fluoropiperidine
CAS No.	1207176-24-6
Molecular Formula	C11H19BrFNO2
Molecular Weight	296.18 g/mol
Synonyms	tert-Butyl 4-(bromomethyl)-4-fluoropiperidine-1-carboxylate; 4-(Bromomethyl)-4-fluoro-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-4-(bromomethyl)-4-fluoropiperidine; 4-Bromomethyl-4-fluoro-1-Boc-piperidine; N-Boc-4-bromomethyl-4-fluoropiperidine; 1-(tert-Butoxycarbonyl)-4-(bromomethyl)-4-fluoropiperidine; 4-Fluoro-4-(bromomethyl)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Bromomethyl-4-Fluoropiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our production adheres to cGMP principles where applicable, ensuring consistent quality and traceability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.