Description

2-(3-(((tert-Butoxycarbonyl)Amino)Methyl)Oxetan-3-Yl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique oxetane ring structure protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile handle for further chemical elaboration while maintaining stereochemical integrity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer drug candidates.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design and synthesis of protease inhibitors due to its structural similarity to amino acid derivatives.
• Peptidomimetics & Bioisosteres: The oxetane ring acts as a valuable bioisostere, used to improve the metabolic stability, solubility, and potency of peptide-based drug leads.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.
• Chemical Biology Probes: Used to create tool compounds for studying enzyme function and biological pathways in academic and industrial research settings.

Basic Information

Product Name	2-(3-(((tert-Butoxycarbonyl)Amino)Methyl)Oxetan-3-Yl)Acetic Acid
CAS No.	1207175-98-1
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	3-[(Boc-amino)methyl]-3-oxetaneacetic acid; 2-[3-[[(tert-Butoxycarbonyl)amino]methyl]oxetan-3-yl]acetic acid; Boc-Amino-oxetane-acetic acid; (3-((((tert-Butoxycarbonyl)amino)methyl)oxetan-3-yl)acetic acid; 2-(3-((((tert-Butoxycarbonyl)amino)methyl)oxetan-3-yl)acetic acid; 1207175-98-1; Boc-AMOA; tert-Butyl N-[(3-carboxymethyloxetan-3-yl)methyl]carbamate
EINECS	Contact for details

Quality Control

Our production of 2-(3-(((tert-Butoxycarbonyl)Amino)Methyl)Oxetan-3-Yl)Acetic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.