Description

Ethyl 1-Tosyl-7-(Trifluoromethylsulfonyloxy)-1H-Pyrrolo[3,2-C]Pyridine-6-Carboxylate is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique triflate and tosyl protecting groups enable precise, site-selective coupling reactions. Its primary utility is in the pharmaceutical and agrochemical R&D sectors, serving as a key intermediate for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel kinase inhibitors, anticancer agents, and other small-molecule therapeutics targeting pyrrolopyridine-based scaffolds.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides that require the incorporation of the trifluoromethylsulfonyloxy (triflate) moiety for enhanced biological activity.
• Cross-Coupling Reactions: The reactive triflate group makes it an excellent electrophile for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to introduce complex aryl and heteroaryl groups.
• Chemical Biology & Probe Development: Serves as a versatile building block for creating chemical probes and labeled compounds used in target identification and mechanistic studies.
• Material Science Research: Potential intermediate for synthesizing organic electronic materials and ligands for catalytic systems, leveraging its electron-deficient heterocyclic core.

Basic Information

Item	Details
Product Name	Ethyl 1-Tosyl-7-(Trifluoromethylsulfonyloxy)-1H-Pyrrolo[3,2-C]Pyridine-6-Carboxylate
CAS No.	1207175-44-7
Molecular Formula	C20H17F3N2O7S2
Molecular Weight	518.48 g/mol
Synonyms	Ethyl 1-(4-Methylbenzenesulfonyl)-7-(((trifluoromethyl)sulfonyl)oxy)-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; 1H-Pyrrolo[3,2-c]pyridine-6-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-7-[[(trifluoromethyl)sulfonyl]oxy]-, ethyl ester; Ethyl 1-Tosyl-7-triflyloxy-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; 7-Trifluoromethanesulfonyloxy-1-tosyl-1H-pyrrolo[3,2-c]pyridine-6-carboxylic acid ethyl ester; Tosyl Pyrrolopyridine Triflate Ester; Advanced Pyrrolopyridine Triflate Building Block
EINECS	Contact for details

Quality Control

Our Ethyl 1-Tosyl-7-(Trifluoromethylsulfonyloxy)-1H-Pyrrolo[3,2-C]Pyridine-6-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.