Description

Spiro[Benzofuran-2(3H),4'-Piperidine]-1'-Carboxylic Acid, 3-Oxo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Drug Discovery & Medicinal Chemistry: Serves as a versatile scaffold for constructing spirocyclic compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Research & Development (R&D): Used in route scouting and optimization for the scalable production of target APIs.
• Academic Research: Employed in synthetic organic chemistry research to explore new reactions and methodologies involving spiroheterocycles.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific projects.

Basic Information

Product Name	Spiro[Benzofuran-2(3H),4'-Piperidine]-1'-Carboxylic Acid, 3-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	1207163-87-8
Molecular Formula	C18H23NO4
Molecular Weight	317.38 g/mol
Synonyms	tert-Butyl 3-oxospiro[benzofuran-2(3H),4'-piperidine]-1'-carboxylate; 1'-Boc-3-oxospiro[benzofuran-2(3H),4'-piperidine]; Spiro[benzofuran-2(3H),4'-piperidine]-1'-carboxylic acid, 3-oxo-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 3-oxospiro[1-benzofuran-2(3H),4'-piperidine]-1'-carboxylate; 3-Oxospiro[benzofuran-2(3H),4'-piperidine]-1'-carboxylic acid tert-butyl ester; Boc-protected 3-oxospiro[benzofuran-2(3H),4'-piperidine]; 1207163-87-8
EINECS	Contact for details

Quality Control

Our Spiro[Benzofuran-2(3H),4'-Piperidine]-1'-Carboxylic Acid, 3-Oxo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), related substances, and other critical parameters is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.