Description

3-Trifluoromethoxy-Pyridin-2-Ylamine is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core substituted with a trifluoromethoxy group and an amine functionality. This compound is valued for its role in modulating the physicochemical and metabolic properties of active pharmaceutical ingredients, making it a critical building block in modern drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services under cGMP conditions.

Basic Information

Product Name	3-Trifluoromethoxy-Pyridin-2-Ylamine
CAS No.	1206981-49-8
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	2-Amino-3-(trifluoromethoxy)pyridine; 3-(Trifluoromethoxy)pyridin-2-amine; 2-Pyridinamine, 3-(trifluoromethoxy)-; 3-Trifluoromethoxy-2-aminopyridine; 3-Trifluoromethoxypyridin-2-ylamine; 2-Amino-3-trifluoromethoxypyridine; 3-(Trifluoromethoxy)-2-pyridinamine
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethoxy-Pyridin-2-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with ICH guidelines and supports development from research to commercial scale under current Good Manufacturing Practice (cGMP) standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.