Description

2-Chloro-3-(Difluoromethoxy)Pyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and difluoromethoxy substituents, makes it an essential intermediate for creating novel compounds with tailored properties. This product is primarily targeted at research and development teams in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the difluoromethoxy group.
• Material Science Research: Serves as a precursor for specialty chemicals, liquid crystals, and advanced polymers requiring specific fluorine-containing motifs.
• Chemical Biology & Medicinal Chemistry: A valuable scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in custom synthesis projects and process development.

Basic Information

Product Name	2-Chloro-3-(Difluoromethoxy)Pyridine
CAS No.	1206977-80-1
Molecular Formula	C6H4ClF2NO
Molecular Weight	179.55 g/mol
Synonyms	2-Chloro-3-(difluoromethoxy)pyridine; 3-(Difluoromethoxy)-2-chloropyridine; Pyridine, 2-chloro-3-(difluoromethoxy)-; 2-Chloro-3-difluoromethoxypyridine; 1206977-80-1
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-(Difluoromethoxy)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP principles where applicable to support our customers in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The compound is light-sensitive (store away from light) and should be handled with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.