Description

tert-Butyl 2-Benzyl-1-Oxo-2,5-Diazaspiro[3.4]Octane-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic architecture.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component in the linker or warhead sections of bifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Academic Research: Employed in university and institutional labs for pioneering studies in synthetic methodology and novel heterocycle formation.

Basic Information

Product Name	tert-Butyl 2-Benzyl-1-Oxo-2,5-Diazaspiro[3.4]Octane-5-Carboxylate
CAS No.	1206970-01-5
Molecular Formula	C18H24N2O3
Molecular Weight	316.40 g/mol
Synonyms	5-Boc-2-benzyl-2,5-diazaspiro[3.4]octan-1-one; tert-Butyl 2-benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate; 2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 2-benzyl-1-oxo-, 1,1-dimethylethyl ester; 2-Benzyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylic acid tert-butyl ester; 2-Benzyl-2,5-diazaspiro[3.4]octan-1-one-5-carboxylic acid tert-butyl ester; BOC-2-Benzyl-2,5-diazaspiro[3.4]octan-1-one; CAS 1206970-01-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Benzyl-1-Oxo-2,5-Diazaspiro[3.4]Octane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced to meet relevant ICH guidelines and can supply material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.