Description

3-(Cyclobutanecarboxamido)-[1,2,4]Triazolo[4,3-A]Pyridine-8-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a fused triazolopyridine core. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for oncology, antiviral, and central nervous system (CNS) applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of investigational drug candidates and novel APIs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Used in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• Antiviral Agent Synthesis: Employed as a building block for compounds being evaluated for antiviral activity.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	3-(Cyclobutanecarboxamido)-[1,2,4]Triazolo[4,3-A]Pyridine-8-Carboxylic Acid
CAS No.	1206969-16-5
Molecular Formula	C₁₂H₁₂N₄O₃
Molecular Weight	260.25 g/mol
Synonyms	3-(Cyclobutanecarboxamido)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylic acid; 8-Carboxy-3-(cyclobutanecarboxamido)[1,2,4]triazolo[4,3-a]pyridine; [1,2,4]Triazolo[4,3-a]pyridine-8-carboxylic acid, 3-[(cyclobutanecarbonyl)amino]-; 3-(Cyclobutanecarbonylamino)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylic acid; 1206969-16-5; UNII-5F5N8T3F0I; 5F5N8T3F0I
EINECS	Contact for details

Quality Control

Our 3-(Cyclobutanecarboxamido)-[1,2,4]Triazolo[4,3-A]Pyridine-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.