Description

5-Ethynylpyridin-3-Ylboronic Acid is a high-value boronic acid derivative featuring a pyridine core substituted with an ethynyl group. This compound is a critical building block in modern synthetic chemistry, prized for its dual functionality that enables the construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between the boronic acid moiety and aryl/vinyl halides, essential for synthesizing biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, leveraging its ability to introduce the ethynylpyridine scaffold.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysis, and novel polymers where conjugated systems are required.
• Chemical Biology Probes: Acts as a handle for bioorthogonal conjugation strategies, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), due to the presence of the terminal alkyne group.

Basic Information

Product Name	5-Ethynylpyridin-3-Ylboronic Acid
CAS No.	1206681-16-4
Molecular Formula	C7H6BNO2
Molecular Weight	146.94 g/mol
Synonyms	5-Ethynyl-3-pyridineboronic Acid; (5-Ethynylpyridin-3-yl)boronic Acid; 3-Borono-5-ethynylpyridine; 5-Ethynylpyridine-3-boronic Acid; 5-Ethynyl-3-pyridinylboronic Acid; Boronic acid, B-(5-ethynyl-3-pyridinyl)-
EINECS	Contact for details

Quality Control

Our 5-Ethynylpyridin-3-Ylboronic Acid is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the rigorous standards expected in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.