Description

tert-Butyl 2-Bromo-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate is a high-value, protected heterocyclic building block essential for advanced organic synthesis. This compound is specifically designed to serve as a key intermediate in the construction of complex nitrogen-containing molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small molecule therapeutics targeting various diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the naphthyridine core for bioactivity.
• Chemical Biology & Probe Development: Serves as a versatile scaffold for creating molecular probes to study biological pathways and enzyme functions.
• Material Science Research: Potential building block for the synthesis of novel organic ligands and functional materials with specific electronic properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce diverse functional groups.
• Medicinal Chemistry SAR Studies: Enables rapid structure-activity relationship (SAR) exploration by allowing modifications at the 2-position of the naphthyridine ring system.

Basic Information

Product Name	tert-Butyl 2-Bromo-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate
CAS No.	1206247-74-6
Molecular Formula	C13H17BrN2O2
Molecular Weight	313.19 g/mol
Synonyms	2-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylic acid tert-butyl ester; 6-Boc-2-bromo-5,6,7,8-tetrahydro-1,6-naphthyridine; tert-Butyl 2-bromo-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate; 2-Bromo-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; 2-Bromo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylic acid, 1,1-dimethylethyl ester; Boc-2-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Bromo-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.