Description

2-Bromo-5-(n-Boc-Piperidin-4-Yl)Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a bromopyridine core and a protected piperidine moiety. This compound matters as a versatile and crucial building block for medicinal chemists, enabling the synthesis of complex molecules with potential therapeutic applications. It is primarily needed by research and development teams in the pharmaceutical and biotechnology industries for drug discovery programs, particularly in the development of kinase inhibitors and other small-molecule active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for oncology and central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive bromine site and protected amine functionality.
• Kinase Inhibitor Development: Serves as a core scaffold or substituent in the design and synthesis of protein kinase inhibitors.
• Chemical Library Synthesis: Employed in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological evaluation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke intermediates for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-Bromo-5-(n-Boc-Piperidin-4-Yl)Pyridine
CAS No.	1206247-72-4
Molecular Formula	C15H21BrN2O2
Molecular Weight	341.25 g/mol
Synonyms	2-Bromo-5-(1-Boc-4-piperidinyl)pyridine; 2-Bromo-5-(1-tert-Butoxycarbonyl-4-piperidinyl)pyridine; 5-(1-Boc-piperidin-4-yl)-2-bromopyridine; tert-Butyl 4-(6-bromopyridin-3-yl)piperidine-1-carboxylate; 1-Boc-4-(6-bromo-3-pyridyl)piperidine; 1206247-72-4; 2-Bromo-5-(N-Boc-piperidin-4-yl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(n-Boc-Piperidin-4-Yl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.