Description

tert-Butyl 4-(4-Aminopyridin-2-yl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a protected amine and an aminopyridine moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries to create potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Kinase Inhibitor Development: The aminopyridine-piperazine scaffold is valuable for constructing potential inhibitors of various kinases, a major class of therapeutic targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities and improve drug-like properties.
• Process Chemistry & Scale-Up: Serves as a defined starting material for developing robust and scalable synthetic routes to candidate drugs under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: The reactive amine group allows for conjugation to other molecules, useful in creating chemical probes for biological assays or antibody-drug conjugates (ADCs).

Basic Information

Product Name	tert-Butyl 4-(4-Aminopyridin-2-yl)piperazine-1-carboxylate
CAS No.	1206247-69-9
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	1-Boc-4-(4-amino-2-pyridyl)piperazine; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-4-amine; tert-Butyl 4-(4-amino-2-pyridinyl)-1-piperazinecarboxylate; 1-Piperazinecarboxylic acid, 4-(4-amino-2-pyridinyl)-, 1,1-dimethylethyl ester; 4-(4-Aminopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester; BOC-4-(4-aminopyridin-2-yl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Aminopyridin-2-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.