Description

n-(5-(4-(Bromomethyl)Phenyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Cyclopropanecarboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique triazolopyridine core functionalized with a reactive bromomethyl group. This compound is of significant commercial importance as a key building block in the synthesis of novel, small-molecule drug candidates, particularly in oncology and targeted therapies. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development for new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational drugs targeting specific biological pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile reactive site.
• Kinase Inhibitor Development: The triazolopyridine scaffold is commonly employed in the design of potent and selective kinase inhibitors for cancer treatment.
• Bioconjugation & Prodrug Synthesis: The bromomethyl moiety allows for efficient conjugation to antibodies, peptides, or other targeting ligands, or for creating prodrug formulations.
• Chemical Biology Probes: Utilized in the development of chemical probes to study enzyme function and cellular processes.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale manufacturing under current Good Manufacturing Practice (cGMP) conditions where required.

Basic Information

Product Name	n-(5-(4-(Bromomethyl)Phenyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Cyclopropanecarboxamide
CAS No.	1206163-59-8
Molecular Formula	C18H15BrN4O
Molecular Weight	383.24 g/mol
Synonyms	Cyclopropanecarboxamide, N-[5-[4-(bromomethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-; 1206163-59-8; N-(5-(4-(Bromomethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide; UNII-7V8J9C0K1F; 7V8J9C0K1F; AKOS040759626; CS-0445774; FT-0773296
EINECS	Contact for details

Quality Control

Our n-(5-(4-(Bromomethyl)Phenyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Cyclopropanecarboxamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided for each lot, and custom synthesis to meet specific purity grades (e.g., >98%, >99%) or cGMP standards is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.