Description

Filgotinib is a potent and selective Janus kinase 1 (JAK1) inhibitor, a key pharmaceutical active ingredient in the development of advanced immunomodulatory therapies. Its high selectivity profile makes it a critical component for researchers and manufacturers targeting specific inflammatory pathways with reduced off-target effects. This compound is essential for pharmaceutical R&D and production, particularly in the development of treatments for autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Filgotinib CAS NO 1206161-97-8 represents a significant advancement in targeted therapeutic agents.

Application

• Primary active pharmaceutical ingredient (API) in the formulation of JAK inhibitor-based drugs.
• Key intermediate in advanced pharmaceutical research for autoimmune and inflammatory conditions.
• Critical reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Used in preclinical and clinical studies investigating the efficacy of selective JAK1 inhibition.
• Essential material for the development of novel therapeutics for rheumatoid arthritis (RA).
• Research chemical in immunological studies to understand JAK-STAT signaling pathways.
• Potential use in the development of treatments for ulcerative colitis and Crohn's disease.
• Building block for medicinal chemistry programs aimed at creating next-generation immunomodulators.

Basic Information

Product Name	Filgotinib
CAS No.	1206161-97-8
Molecular Formula	C₂₁H₁₇N₇O₂S
Molecular Weight	431.47 g/mol
Synonyms	GLPG0634; G-0634; Filgotinib (GLPG0634); 2-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]pyrimidine-5-carboxamide; 2-[(3R,4R)-4-Methyl-3-[methyl(1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]-5-pyrimidinecarboxamide; 2-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)pyrimidine-5-carboxamide; JAK1 Inhibitor GLPG0634; GS-6034
EINECS	Contact for details

Quality Control

Our Filgotinib is manufactured under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our rigorous specifications. We support development efforts aligned with GMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.