Description

Etrasimod Arginine is a high-purity, non-hygroscopic salt form of the selective sphingosine-1-phosphate (S1P) receptor modulator, Etrasimod. This compound is a critical pharmaceutical intermediate and reference standard in the development and quality control of advanced immunomodulatory therapies. It is primarily utilized by research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) engaged in the production of innovative treatments for autoimmune and inflammatory diseases.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control (QC/QA) testing of Etrasimod-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and scale-up manufacturing processes for finished dosage forms.
• Preclinical & Clinical Research: Employed in pharmacological studies, bioavailability assessments, and formulation development for new therapeutic applications.
• Regulatory Submissions: Provides essential characterization data for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).
• Impurity Profiling: Acts as a benchmark in the identification and quantification of related substances and degradation products.

Basic Information

Product Name	Etrasimod Arginine
CAS No.	1206123-97-8
Molecular Formula	C35H48N8O7
Molecular Weight	692.81 g/mol
Synonyms	APD334 arginine salt; Etrasimod L-arginine; (R)-5-(4-((1R,2S,3R)-2,3-Dihydroxy-1,4-dioxaspiro[4.5]decan-8-yl)but-1-yn-1-yl)-N-(4-((5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)amino)quinazolin-2-yl)pyrimidine-2-carboxamide arginine salt; UNII-7F4K9Q3VQ5; S1P receptor modulator arginine salt
EINECS	Contact for details

Quality Control

Our Etrasimod Arginine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS). We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, ensuring compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C, in a dry environment. The material is hygroscopic; protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.