Description

Etrasimod CAS NO 1206123-37-6 is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. This compound is of significant interest for its targeted mechanism of action in modulating immune cell trafficking. It is primarily required by pharmaceutical research and development organizations, contract manufacturing organizations (CMOs), and academic institutions engaged in immunology and autoimmune disease research.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key active component in the formulation of investigational and approved medicinal products.
• Immunology Research: Used as a critical reference standard and tool compound in preclinical studies to investigate S1P receptor biology and signaling pathways.
• Autoimmune Disease R&D: Central to the development of novel therapeutics for conditions such as ulcerative colitis, Crohn's disease, and atopic dermatitis.
• Process Development & Scale-up: Supplied to CMOs and internal process chemistry teams for route optimization, impurity profiling, and manufacturing campaign support.
• Analytical Method Development: Employed as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical techniques.
• Regulatory Submissions: Provides the necessary quality-controlled material for stability studies, toxicology batches, and clinical trial material (CTM) manufacturing required for regulatory filings (e.g., IND, NDA).

Basic Information

Product Name	Etrasimod
CAS No.	1206123-37-6
Molecular Formula	C27H29FN2O4
Molecular Weight	464.53 g/mol
Synonyms	APD334; Etrasimodum; 2-[(4-[(3-[(Z)-3-Cyclopentyl-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]amino)propyl]phenyl)amino]-2-oxoacetic acid; (2Z)-3-Cyclopentyl-3-[4-(trifluoromethoxy)phenyl]-N-[4-[(2-oxo-2-[[(phenylmethyl)amino]carbonyl]amino)phenyl]butyl]-2-propenamide (non-preferred IUPAC); S1P Receptor Modulator APD334
EINECS	Contact for details

Quality Control

Our Etrasimod is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identification by IR and MS, and stringent control of specified impurities and residual solvents to meet pharmaceutical research grade standards. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Assay (HPLC)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.