Description

6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester, (4R)- is a high-value, stereochemically defined spirocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical chiral intermediate in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical and biotechnology companies engaged in the discovery and scale-up of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in neuroscience and CNS drug discovery.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the development of robust, scalable synthetic routes for API manufacturing.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential incorporation as a linker or spacer component due to its rigid, three-dimensional spirocyclic structure.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecules with high enantiomeric purity.
• Chemical Biology Probes: Can be used to create tool compounds for studying biological targets and pathways.

Basic Information

Item	Detail
Product Name	6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester, (4R)-
CAS No.	1205542-21-7
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	(4R)-4-Hydroxy-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; tert-Butyl (4R)-4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate; (R)-tert-Butyl 4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate; (4R)-4-Hydroxy-6-azaspiro[2.5]octane-6-carboxylic acid 1,1-dimethylethyl ester; 6-Azaspiro[2.5]octane-6-carboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester, (4R)-; (R)-4-Hydroxy-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; (R)-tert-Butyl 4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate; 1205542-21-7
EINECS	Contact for details

Quality Control

Our 6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester, (4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and traceability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. For long-term storage, consider storing under nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.