Description

3-((4-Nitrobenzylamino)Methyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold and a nitrobenzyl-protected amine group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors due to its piperidine core and protected amine functionality.
• Ligand and Receptor Modulator Development: Employed in the creation of novel ligands for G-protein coupled receptors (GPCRs) and other biological targets.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API batches.
• Academic Research: Used in university and institutional laboratories for chemical biology studies and the development of new synthetic methodologies.

Basic Information

Product Name	3-((4-Nitrobenzylamino)Methyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1204809-97-1
Molecular Formula	C19H29N3O4
Molecular Weight	363.45 g/mol
Synonyms	1-Boc-3-((4-nitrobenzylamino)methyl)piperidine; tert-Butyl 3-(((4-nitrophenyl)methyl)aminomethyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-((4-nitrobenzylamino)methyl)piperidine; 3-[(4-Nitrobenzylamino)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; N-(4-Nitrobenzyl)-N-((1-Boc-piperidin-3-yl)methyl)amine; 3-((4-Nitrobenzylamino)Methyl)Piperidine-1-Carboxylic Acid 1,1-Dimethylethyl Ester; 1-Boc-3-((p-nitrobenzylamino)methyl)piperidine
EINECS	Contact for details

Quality Control

Our production of 3-((4-Nitrobenzylamino)Methyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is characterized and released according to in-house specifications aligned with ICH guidelines. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as identity, purity (by HPLC), and impurity profile. We support cGMP-compliant manufacturing for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in the original packaging away from direct light exposure. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.