Description

Epacadostat (INCB024360) is a potent, selective, and orally bioavailable small-molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1). This compound matters as a key research tool and clinical candidate for modulating the tumor microenvironment and investigating immuno-oncology pathways. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in developing novel cancer immunotherapies and studying tryptophan metabolism.

Application

• Immuno-oncology Research: A critical reference standard and active agent for studying the IDO1 pathway's role in tumor immune evasion.
• Preclinical Development: Used in in vitro and in vivo models to evaluate the efficacy of IDO1 inhibition in combination with other therapies.
• Biochemical Assays: Serves as a potent inhibitor in high-throughput screening and enzymatic assays targeting IDO1 activity.
• Clinical Reference Material: Utilized as a benchmark compound in analytical method development and validation for pharmacokinetic studies.
• Mechanistic Studies: Employed to investigate the downstream effects of tryptophan catabolism on T-cell function and dendritic cell activity.

Basic Information

Product Name	Epacadostat (INCB024360)
CAS No.	1204669-58-8
Molecular Formula	C15H13FN4O3
Molecular Weight	316.29 g/mol
Synonyms	INCB024360; INCB 024360; INCB-024360; 4-[[2-[(3S)-3-Amino-3-carboxypropyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy]-2-fluorobenzoic acid; (S)-1-((S)-2-(3-(4-(2-Carboxy-3-fluorophenoxy)-1-oxoisoindolin-2-yl)propanamido)propanoyl) pyrrolidine-2-carboxylic acid; Epacadostatum.
EINECS	Contact for details

Quality Control

Our Epacadostat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to warm to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.